Real Madrid have beaten Barcelona 2-1 to win this season's first Clasico and it was David Alaba and Lucas Vazquez who did the damage as Sergio Aguero's strike came too little too late for the hosts.
Ronald Koeman's men started brightly in Catalonia but it only lasted as long as it took for Alaba and Real's counterattack to rip through Barca's thin defense to fire home a stunning opener.
Watford 4 -1 Manchester United
João Pedro (90'+2minutes),
van de Beek (50'minutes),
Maguire (Dismissed at69'minutes)
Harry Maguire was sent off as beleaguered Manchester United manager Ole Gunnar Solskjaer suffered more misery in an emphatic defeat at Watford.
The Hornets should have gone ahead when Scott McTominay bundled over forward Joshua King inside the box, but goalkeeper David de Gea saved Ismaila Sarr's penalty - then kept out his retake, ordered by the referee for encroachment.
New Barcelona manager Xavi celebrated his first game in charge at the Nou Camp with a slim derby victory over Espanyol in La Liga.
Although the home fans were able to claim bragging rights over their city rivals, the visitors could easily have won the game having wasted numerous chances in the second half.
Xavi eventually saw his side take the lead seconds after the restart through a Memphis Depay penalty.
The win puts Barca sixth in the table.
Manchester City Derby Highlights! - Manchester United manager Ole Gunnar Solskjaer: "It’s very disappointing. Last week, it felt like we made a step forward, this is a big step backwards. It is a way of losing we don’t like. You want to see a better Man United than that.
"When you concede the first goal in an unfortunate way as early as that it makes it difficult. They pressed us really well. We never got to the level we need to be at to beat good teams.
Cristiano Ronaldo completes comeback to relieve pressure on Ole Gunnar Solskjaer
Match report as Manchester United come from two goals down at half-time to beat Atalanta 3-2; second-half goals from Marcus Rashford, Harry Maguire brought United level before Cristiano Ronaldo completed the turnaround; victory relieves pressure on boss Ole Gunnar Solskjaer
Manchester City came back from behind to beat Paris St-Germain and secure qualification for the Champions League last 16 - doing so as Group A winners.
City's outstanding display reaped the reward it deserved, as they showed character as well as class after Kylian Mbappe swept PSG into a 50th-minute lead.
PSG manager Mauricio Pochettino, heavily linked with Manchester United following Ole Gunnar Solskjaer's sacking, was left disappointed as City hit back in style to turn the game around.
Real Madrid reached the Champions League knockout stage for the 25th successive year with a comfortable win against Sheriff Tiraspol in Moldova.
David Alaba opened the scoring with a free-kick that deflected beyond goalkeeper Giorgos Athanasiadis.
Toni Kroos added a second before the break, firing in off the crossbar, while Karim Benzema then made it three.
It means Real Madrid are through with a game to spare, as are Inter Milan, who beat Shakhtar Donetsk earlier.
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